VISTA Regulates the Development of Protective Antitumor Immunity

VISTA Regulates the Development of Protective Antitumor Immunity.

V-domain Ig suppressor of T-cell activation (VISTA) is a novel negative checkpoint ligand that is homologous to PD-L1 and suppresses T-cell activation. This study demonstrates the multiple mechanisms whereby VISTA relieves negative regulation by hematopoietic cells and enhances protective antitumor immunity. VISTA is highly expressed on myeloid cells and Foxp3(+)CD4(+) regulatory cells, but not...

Microenvironment and Immunology VISTA Regulates the Development of Protective Antitumor Immunity

V-domain Ig suppressor of T-cell activation (VISTA) is a novel negative checkpoint ligand that is homologous to PD-L1 and suppresses T-cell activation. This study demonstrates the multiple mechanisms whereby VISTA relieves negative regulation by hematopoietic cells and enhances protective antitumor immunity. VISTA is highly expressed on myeloid cells and Foxp3þCD4þ regulatory cells, but not on ...

Induction of Protective Antitumor Immunity

sion and Promotes Protective Antitumor Immunity

ownload or-associated immunosuppressive strategies, such as lack of tumor antigen recognition and failure phocyte activation and homing, resist the development of tumor-specific immunity and hamper the ne response–mediated elimination of cancerous cells. In this report, we show that reovirus virotherverrides such a tumor immune evasion and establishes clinically meaningful antitumor immunity le...

Scavenger receptor-A negatively regulates antitumor immunity.

The scavenger receptor-A (SR-A), originally recognized by its ability to internalize modified lipoproteins, has largely been studied in relation to atherosclerosis as well as innate immunity against pathogen infection. SR-A was recently shown to be a receptor on antigen-presenting cell for heat shock protein (HSP) and was implicated in the cross-presentation of HSP-chaperoned antigens. Here, we...